Composition for establishing immunological tolerance

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 39/35 (2006.01)

Patent

CA 1127538

"COMPOSITION FOR ESTABLISHING IMMUNOLOGICAL TOLERANCE" ABSTRACT OF THE DISCLOSURE A water-soluble non-immunogenic carrier, namely carboxymethyl cellulose, is provided which, in attachment to allergens or other haptens, is capable of inducing an immunological tolerance in an individual of a mammalian species to the allergen or hapten. The allergen or hapten is attached to each of a plurality of the carboxyl groups of carboxymethyl cellulose. Tolerance has been induced in mice to three particular haptens, namely 2,4-dinitrophenyl, penicillin G and fluorescein in the specific embodiments of the present invention.

344873

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