Composition for filling bone defects

Details Composition for filling bone defects Composition for filling bone defects

A - Human Necessities

61

L

A61L 27/36 (2006.01) A61L 27/44 (2006.01) A61L 27/50 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2699487

The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5 -7.5.

L'invention concerne une composition osseuse façonnable améliorée destinée à être appliquée sur un site de défaut osseux afin d'activer une nouvelle croissance osseuse en ce site, qui comprend un composé induisant une nouvelle croissance osseuse à base de particules osseuses d'allogreffe lyophilisées et déminéralisées de taille comprise entre environ 100 et 850 microns. Les particules osseuses sont mélangées dans une combinaison d'excipient et de support contenant de la carboxyméthylcellulose, de l'hyaluronate de sodium, et un tampon phosphate de sodium salin. Le composant de carboxyméthylcellulose du support constitue d'environ 5,0 à environ 11,0 % de la composition et le composant d'hyaluronate de sodium du support constitue d'environ 0,3 à environ 0,7 % de la composition, et le pH de celle-ci est compris entre 6,5 et 7,5.

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