Composition for inducing humoral anergy to an immunogen

Details Composition for inducing humoral anergy to an immunogen Composition for inducing humoral anergy to an immunogen

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) A61K 47/48 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2076648

Conjugates of stable nonimmunogenic polymers and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.

L'invention se rapporte à des conjugués de polymères non immunogènes stables et à des analogues d'immunogènes qui possèdent la capacité de liaison aux lymphocytes B spécifique de l'immunogène mais qui sont dépourvus des épitopes des lymphocytes T, et qui lorsqu'ils sont introduits dans l'organisme d'un individu, induisent une anergie humorale à l'immunogène. C'est pourquoi ces conjugués sont utiles pour traiter les pathologies véhiculées par les anticorps, qui sont causées par des immunogènes propres à l'organisme ou étrangers.

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