Composition for inhibiting adhesion

A - Human Necessities – 61 – K

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Details

A61K 31/765 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2640409

There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel state by body temperature and is thus stably coated within tissues whereby it functions as a membrane inhibiting adhesion and as time lapses, it is degraded into low molecular weight surfactants and bio-degradable single molecular substances whereby they can be absorbed into body and the degraded products can bring about secondary adhesion inhibiting effects.

La présente invention concerne une composition inhibant l'adhérence qui comprend des polymères dissous dans une solution aqueuse et présente une sensibilité à la température caractérisée par une transition thermodépendante de la phase sol à la phase gel. A l'état de sol, la solution polymère passe à l'état de gel sous l'effet de la température du corps et est donc appliquée de manière stable à l'intérieur des tissus où elle agit comme une membrane inhibant l'adhérence. Avec le temps, elle se dégrade en tensioactifs à faible poids moléculaire et en substances mono-moléculaires bio-dégradables qui peuvent être absorbés dans l'organisme, les produits de dégradation pouvant procurer des effets anti-adhérence secondaires.

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