Composition for iontophoretic delivery of rotigotine

Details Composition for iontophoretic delivery of rotigotine Composition for iontophoretic delivery of rotigotine

A - Human Necessities

61

K

A61K 31/381 (2006.01) A61K 9/00 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2505040

By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems.

Le procédé décrit consiste à utiliser une composition contenant de la rotigotine et au moins un sel de chlorure à raison d'une concentration comprise entre 1 et 140 mmol/l, cette composition présentant un pH compris entre 4 et 6,5 dans un dispositif iontophorétique pour le traitement de la maladie de Parkinson. Ce procédé permet d'obtenir un flux de rotigotine à travers la couche cornée qui est plus important que celui obtenu précédemment avec les dispositifs conventionnels à diffusion passive.

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