C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/9, 167/103.8
C07K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 38/14 (2006.01) A61K 39/39 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1338948
The present invention provides a novel lipophilic dissacharide-tripeptide, derivative of the known base compound muramyl dipeptide (MDP) for activating human monocytes with subsequent destruction of tumor cells. The compound of the invention is preferably encapsulated into multilamellar liposomes, which can be formed from phosphatidyl choline and phosphatidyl glycerol. The compound of the invention has the general formula (I): (I) Image wherein R1 is (C1-C5) alkyl, R2 is (C1-C5) alkyl, R3 and R4 are individually (C6-C30) alkyl groups having about 0-4 double bonds, and X is a peptidyl residue; and the pharmaceutically acceptable salts thereof.
605022
Cornelius Dennis A.
Swenson Karl E.
Vosika Gerald J.
Endorex Corp.
Gowling Lafleur Henderson Llp
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