Composition for nucleic-acid transfection

Details Composition for nucleic-acid transfection Composition for nucleic-acid transfection

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2656228

A composition for nucleic-acid introduction which is lowly cytotoxic and is improved in the intracellular introduction of a nucleic acid to be introduced and in the intracellular expression thereof. The composition for the intracellular introduction of a nucleic acid comprises a compound represented by the following formula (I) (wherein R1 and R2 are the same or different and each means a C12-22 (un)saturated hydrocarbon group; R3 means C1-6 alkyl or C1-6 hydroxyalkyl; m means an integer of 1-10; and X means halogeno) and a phospholipid. (I)

L'invention concerne une composition destinée à la pénétration d'un acide nucléique qui présente une faible cytotoxicité, une meilleure capacité de pénétration intracellulaire d'un acide nucléique à faire pénétrer, ainsi qu'une meilleure capacité d'expression intracellulaire. Cette composition contient un composé représenté par la formule suivante (I) (dans laquelle R<SUP>1</SUP> et R<SUP>2</SUP> sont identiques ou différents et représentent chacun un groupe hydrocarboné (in)saturé C<SUB>12-22</SUB>; R<SUP>3</SUP> représente alkyl C<SUB>1-6</SUB> ou hydroxyalkyl C<SUB>1-6</SUB>; m est un nombre entier compris entre 1 et 10, et X désigne halogène) et un phospholipide. (I)

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