Composition for prophlaxis or treatment of pulmonary...

Details Composition for prophlaxis or treatment of pulmonary... Composition for prophlaxis or treatment of pulmonary...

A - Human Necessities

61

K

A61K 38/12 (2006.01) C07K 7/64 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2164165

Cyclic hexapeptides having antagonistic activity on endothelin receptors of the formula [I]: Image [I] wherein X and Y each is an .alpha.-amino acid residue having D-, L-form or DL-form, A is a D-acidic-.alpha.-amino acid residue, B is a neutral-.alpha.-amino acid residue having D- or L-form, C is an L-.alpha.-amino acid residue and E is a D-.alpha.-amino acid residue having an aromatic ring group can be effectively used for prophylaxis and/or treatment of pulmonary circulatory diseases.

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