Composition for proteasome inhibition

Details Composition for proteasome inhibition Composition for proteasome inhibition

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 31/336 (2006.01) A61K 31/396 (2006.01)

Patent

CA 2589921

Compositions comprising one or more practically insoluble proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin, substantially increase the solubility of these proteasome inhibitors and facilitate their administration. Such compositions optionally comprise a buffer. Methods of treatment using such compositions are also disclosed

L'invention concerne des compositions qui comprennent: un ou plusieurs inhibiteurs pratiquement insolubles du protéasome, et une cyclodextrine, en particulier une cyclodextrine substituée. Les compositions de l'invention augmentent sensiblement la solubilité des inhibiteurs du protéasome et facilitent leur administration. Ces compositions comprennent éventuellement un tampon. L'invention concerne également des méthodes de traitement utilisant de telles compositions.

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