Composition for rectal delivery of an oxazolidinone...

A - Human Necessities – 61 – K

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Details

A61K 9/02 (2006.01) A61K 9/00 (2006.01) A61K 31/422 (2006.01) A61K 31/5355 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2441854

There is provided a pharmaceutical composition suitable for rectal administration, the composition comprising at least one oxazolidinone antibacterial drug, for example linezolid, in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection, the at least one oxazolidinone being in particulate form having a particle size of about 0.5 ~m to about 150~m, dispersed in a carrier in which the oxazolidinone is poorly soluble. The composition is, for example, a suppository, an enema, a microenema or a rectal capsule.

L'invention concerne une composition pharmaceutique convenant pour une administration par voie rectale. Cette composition contient au moins un médicament d'oxazolidinone antibactérien, par exemple le linezolid, en concentration suffisante pour traiter et/ou prévenir une infection bactérienne Gram positive, la ou les oxazolidinone(s) étant sous forme de particules présentant une taille d'environ 0,5 µm à environ 150µm, dispersées dans un excipient dans lequel l'oxazolidinone est peu soluble. Cette composition est, par exemple, un suppositoire, un lavement, un microlavement ou une capsule rectale.

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