A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2714506
The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a protein or peptide in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non- polymeric material; (c) a protein or peptide covalently conjugated with one or more formulation performance-enhancing compounds. The present invention also provides a method of manufacturing and use of the composition thereof.
L'invention concerne une nouvelle composition liquide appropriée pour la formation in situ d'un système de dépôt pour administrer une protéine ou un peptide de manière contrôlée. La composition de la présente invention comprend : (a) un matériau porteur non polymère hydrophobe; (b) un solvant organique biocompatible miscible dans l'eau qui dissout le matériau non polymère hydrophobe; (c) une protéine ou un peptide conjugué(e) de manière covalente avec un ou plusieurs composés de la formulation améliorant la performance. La présente invention fournit également un procédé de fabrication et d'utilisation de la composition correspondante.
Chien Benjamin
Guarino Andrew
Li Yuhua
Moffat & Co.
Qps Llc
LandOfFree
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