Composition for testing periodontal diseases

Details Composition for testing periodontal diseases Composition for testing periodontal diseases

C - Chemistry, Metallurgy

12

Q

150/3.2

C12Q 1/37 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 1332347

-1- Abstract The present invention is directed to a periodontal disease testing composition which diagnoses or prognosticates contraction or progress of the diseases or diagnoses the therapeutic value by promptly determining peptidase-like enzymatic activity in a specimen. The composition is a combination of a compound of the formula [1] or [2] or a mixture thereof, a chromogen and an oxidase: X-T-Pro-Y [1] or X'-Z'-Arg-Y' [2] wherein Pro is a proline residue; Arg is an arginine residue; X and X' are hydrogen or an amino protecting group, respectively; Y and Y' are each a residue of a compound which can increase the oxidation reaction rate of a chromogen with an oxidase in the presence of oxygen and is attached to the C- terminal of Pro or Arg, respectively; and T and Z' are each an amino acid or peptide residue composed of 0 to 4 amino acids or their protected derivatives the C-terminal of which is attached to the N-terminal of Pro or Arg, respectively.

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