Composition for the inhibition of vascular occlusion

Details Composition for the inhibition of vascular occlusion Composition for the inhibition of vascular occlusion

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61K 35/12 (2006.01) A61L 27/50 (2006.01) A61L 31/00 (2006.01) C12N 11/04 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2222497

Compositions and methods are described for treating hyperplasia of vascular smooth muscle cells and restenosis of blood vessels or accelerated arteriopathy following vascular injury or disease. Endothelial cells are cultured in a biocompatible polymeric matrix which is then implanted. or wrapped around the exterior of a blood vessel. The engrafted matrix-associated endothelial cells inhibit progression or promote regression of intimal hyperplasia or smooth muscle cell proliferation in the vicinity of the blood vessel's inner surface and decreases the incidence of restenosis often associated with vascular hyperplasia.

Compositions et procédés de traitement de l'hyperplasie des cellules des muscles lisses de la paroi vasculaire et de la resténose des vaisseaux sanguins, ou de l'artériopathie accélérée consécutive à une blessure ou une maladie vasculaire. Les cellules endothéliales sont mises en culture dans une matrice polymère biocompatible qui est ensuite implantée ou enroulée autour de l'extérieur d'un vaisseau sanguin. Les cellules endothéliales associées à la matrice greffée inhibent la progression ou favorisent la régression de l'hyperplasie de l'intima ou de la prolifération de cellules des muscles lisses à proximité de la surface intérieure du vaisseau sanguin, et réduisent l'incidence de la resténose souvent associée à l'hyperplasie vasculaire.

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