Composition for the prevention and/or treatment of diseases...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/7028 (2006.01) A61P 1/00 (2006.01) A61P 3/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2670001

The present invention relates to a pharmaceutical composition comprising at least one compound of the formula (I), or one of the pharmaceutically acceptable salts thereof in which R1, R2 and R3 are independently hydrogen or a R7-CO- group, where R7 is a linear, branched or cyclic alkyl, alkene or alkyne group comprising 2 to 24 carbon atoms, R4 is a hydrogen atom or a mannosyl group substituted at position 6 by an R6 moiety chosen from the group comprised of a hydrogen atom, a mono-, a di-, a tri-, a tetra- and a penta-mannosyl; as well as the use of such a composition for the preparation of a drug for the prevention or the treatment of a disease associated with the over-expression of TNF and/or IL-12 in a subject.

La présente invention concerne une composition pharmaceutique comprenant au moins un composé de formule (I) ou l'un de ses sels pharmaceutiquement acceptables dans laquelle R1, R2 et R3 sont indépendamment un hydrogène ou un groupement R7-CO- où R7 est un groupement alkyle, alcène ou alcyne linéaire, ramifié ou cyclique comprenant de 2 à 24 atomes de carbone; R4 est un atome d' hydrogène ou un groupement mannosyl substitué en position 6 par un résidu R6 choisi dans le groupe comprenant un atome d'hydrogène et un groupement R7-CO-; et R5 est choisi dans le groupe comprenant un atome hydrogène, un mono-, un di-, un tri-, un tétra- et un penta-mannosyl; ainsi que l'utilisation d'une telle composition pour la fabrication d'un médicament destiné à la prévention ou au traitement d'une maladie associée à la surexpression du TNF et/ou de l'IL-12 chez un sujet.

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