A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/426 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2572898
Disclosed herein is a composition for the treatment and prevention of allergic inflammatory diseases comprising N-hydroxy-4-{5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4- yl)phenoxy]pentoxy}-benzamidine, 4-{5- [4- (5-isopropyl-2- methyl- 1, 3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine or pharmaceutically acceptable salts. The composition exhibits excellent medicinal effects on allergic inflammatory diseases, with a great reduction in typical chronic inflammation symptoms, such as an increase of eosinophil level in bronchoalveolar lavage fluid, total leukocyte level and eosinophil level in blood, the hypertrophy or hyperplasia of bronchial epithelium due to an increase in the number of mucus cells, a reduction in alveolar surface area resulting from the hypertrophy of alveolar walls, and the infiltration of inflammatory cells.
L'invention concerne une composition pour le traitement et la prévention de maladies inflammatoires allergiques comprenant N-hydroxy-4-{5-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxyl]pentoxy}-benamidine, 4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy}-benzamidine ou des sels acceptables au plan pharmaceutique. Cette composition possède d'excellents effets médicinaux sur les maladies inflammatoires allergiques, avec une réduction importante des symptômes inflammatoires chroniques typiques, tels que l'augmentation du taux d'éosinophiles dans le fluide de lavage broncho-alvéolaire, du taux de leucocytes total et du taux d'éosinophiles dans le sang, l'hypertrophie ou l'hyperplasie de l'épithélium bronchique due à une augmentation du nombre de cellules muqueuses, la réduction de la surface alvéolaire résultant de l'hypertrophie des parois alvéolaires, et l'infiltration de cellules inflammatoires.
Ku Sae Kwang
Lee Jin Soo
Lee Sang Ho
Ryu Jei Man
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Dong Wha Pharmaceutical Co. Ltd.
Dong Wha Pharmaceutical Ind. Co. Ltd.
LandOfFree
Composition for the prevention and treatment of allergic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition for the prevention and treatment of allergic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for the prevention and treatment of allergic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1669923