C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/08 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2498642
Compositions, use , article of manufacture and method for the treatment of a mammal infected with a virus of the Flaviviridae family are provided comprising administration to the infected mammal of a compound having Formula (I), wherein A is selected from: C1 to C6 alkyl and C3 to C6 cycloalkyl; and B is selected from: phenyl or thiazolyl, both of which optionally substituted with a group selected from NH(R1) and NH(CO)R1, wherein R1 is C1 to C6 alkyl; R is OH or a sulfonamide derivative; or a pharmaceutically acceptable salt thereof.
L'invention concerne des compositions, leur utilisation, un article fabriqué et une méthode de traitement d'un mammifère infecté par un virus de la famille des Flaviviridae. Ladite méthode consiste à administrer au mammifère infecté un composé de formule générale (I), dans laquelle A est sélectionné parmi: alkyle C¿1?-C¿6? et cycloalkyle C¿3?-C¿6?; et B est sélectionné parmi: phényle ou thiazolyle, ces deux éléments étant éventuellement substitués par un groupe sélectionné entre NH(R?1¿) et NH(CO)R?1¿, R?1¿ représentant alkyle C¿1?-C¿6?; R représentant OH ou un dérivé sulfonamide; ou un sel acceptable du point de vue pharmaceutique de celui-ci.
Lagace Lisette
Lamarre Daniel
Boehringer Ingelheim International Gmbh
Looper Ywe J.
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