Composition for treating inflammatory bowel disease

Details Composition for treating inflammatory bowel disease Composition for treating inflammatory bowel disease

A - Human Necessities

61

K

A61K 31/355 (2006.01)

Patent

CA 2539025

A method for reducing inflammation in inflammatory bowel disease is disclosed. The method comprises reducing the expression of endothelial cell adhesion molecules in the vasculature of the bowel wall by administering a therapeutic dosage of an effective amount of a blend of vitamin E TPGS and gamma- tocopherol. Gamma-tocopherol is also useful when used alone in the invention. The reduction in endothelial cell adhesion molecules is due to the deactivation of endothelial NFK-B by the composition.

L'invention concerne une méthode de réduction de l'inflammation dans la maladie intestinale inflammatoire. Ladite méthode consiste à réduire l'expression des molécules d'adhésion des cellules endothéliales dans le système vasculaire de la paroi intestinale par administration d'une dose thérapeutique d'une quantité efficace d'un mélange de vitamine E TPGS et de gamma tocophérol. Le gamma tocophérol est également utilisé seul dans l'invention. La réduction des molécules d'adhésion des cellules endothéliales est due à la désactivation du NF<SB>K</SB>-B endothélial par la composition.

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