Composition for treating mycobacterioses

Details Composition for treating mycobacterioses Composition for treating mycobacterioses

A - Human Necessities

61

K

167/102, 167/229

A61K 31/455 (2006.01) A61K 31/44 (2006.01) A61K 31/63 (2006.01)

Patent

CA 1036939

ABSTRACT OF THE DISCLOSURE The specification relates to an oral composition for the treatment of mycobacterioses, such as the treatment of leprosy and tuberculosis, containing an effective amount of isonicotinic acid hydrazide (international non-proprietary name isoniazid, designated herein as INH), an effective amount of 2-propyl-thioisonicotinic acid amide (prothionamide designated herein as PTH) and/or 2-ethyl-thioisonicotinic acid amide (ethionamide designated herein as ETH) and an effective amount of a sulfone and/or a sulfonamide with sustained activity. Suitable sulfones and sulfonamides with sustained activity, among others, are 4,4'-diaminodiphenyl-sulfone designated herein as DDS, sulfamethoxypyridazine and the like, as well as combinations of sulfones with sulfonamides, such as trimethoprimsulfonamides.

206869

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