A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/352 (2006.01)
Patent
CA 2548578
Disclosed is a novel use of apigenin as a chondroregenerative agent, which has the effects of reducing elevated of cartilage destruction markers including total synovial fluid volume and proteoglycan, total proteins and prostaglandin in a synovial fluid, improving the condition of synovial cells, and regenerating cartilage. Also, the present invention discloses a therapeutic agent for osteoarthritis comprising apigenin as an agent regenerating articular cartilage, and a method of treating osteoarthritis using such a therapeutic agent.
Cette invention concerne une nouvelle utilisation de l'apigénine en tant qu'agent chondrorégénérateur, qui a pour effet de réduire des niveaux élevés des marqueurs de destruction cartilagineuse, dont le volume total du fluide synovien ainsi que due protéogylcane, des protéines totales et de la prostaglandine dans le fluide synovien, d'améliorer l'état des cellules synoviales et des régénérer les cartilages. De plus, l'invention concerne un agent thérapeutique pour l'ostéoarthrite contenant de l'apigénine comme agent régénérateur des cartilages et une méthode de traitement de cette pathologie au moyen d'un tel agent thérapeutique. ¿?
Kang Ju Hee
Kim Gyoung Mi
Park Chang Shin
Hwang Sung-Wan
Hwang Sung-Yeoun
Kmsi Co. Ltd.
Smart & Biggar
Yuhan Corporation
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