Composition for treatment of undifferentiated gastric cancer

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/22 (2006.01) A61K 31/337 (2006.01) A61K 31/403 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/513 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2676796

Disclosed are: a therapeutic agent, a kit and a treatment method for undifferentiated-type of gastric cancer; and a pharmaceutical composition, a kit and a treatment method which are more effective on a living body having at least one cell selected from the group consisting of a cell over-expressing FGFR2 and a cell expressing a FGFR2 mutant. A combination of a FGFR2 inhibitor and a therapeutic substance for gastric cancer is more effective on undifferentiated-type of gastric cancer. The combination of a FGFR2 inhibitor and a therapeutic substance for gastric cancer is more effective on a living body having at least one cell selected from the group consisting of a cell over-expressing FGFR2 and a cell expressing a FGFR2 mutant.

L'invention concerne un agent thérapeutique, un kit et un procédé de traitement pour un cancer de l'estomac de type indifférencié; et une composition pharmaceutique, un kit et un procédé de traitement qui sont plus efficaces sur un organisme vivant possédant au moins une cellule choisie parmi le groupe constitué d'une cellule surexprimant le récepteur-2 au facteur de croissance de fibroblastes (FGFR2) et d'une cellule exprimant un FGFR2 mutant. Une combinaison d'un inhibiteur du FGFR2 et d'une substance thérapeutique pour le cancer de l'estomac est plus efficace contre un cancer de l'estomac de type indifférencié. La combinaison d'un inhibiteur du FGFR2 et d'une substance thérapeutique pour le cancer de l'estomac est plus efficace dans un organisme vivant possédant au moins une cellule choisie parmi le groupe constitué d'une cellule surexprimant le récepteur-2 au facteur de croissance de fibroblastes (FGFR2) et d'une cellule exprimant un FGFR2 mutant.

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