Composition having reduced nephrotoxicity comprising a fatty...

Details Composition having reduced nephrotoxicity comprising a fatty... Composition having reduced nephrotoxicity comprising a fatty...

A - Human Necessities

61

K

167/103.9

A61K 31/20 (2006.01) A61K 35/407 (2006.01) A61K 35/60 (2006.01) A61K 38/13 (2006.01)

Patent

CA 1302879

ABSTRACT OF THE DISCLOSURE Compositions comprising cyclosporine in combination with a vehicle comprising a fatty acid component comprising a fatty acid of the omega-3 or a pharmacologically acceptable salt thereof. Methods for mediating the nephrotoxic effect of cyclosporine and for reducing cyclosporine induced renal prostaglandins comprising administering said cyclosporine in combination with said fatty acid component or a pharmacologi- cally acceptable salt thereof. Eicosapentaenoic acid and docosahexanoic acid are preferred omega-3 fatty acids of the present invention. The compositions and methods of the present invention are useful in clinical and preclinical therapeutic cyclosporine treatment of animals, including humans. A24.4.WP 042987

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