C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 5/16 (2006.01) C12N 9/64 (2006.01) C12N 15/62 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2262056
This invention relates to a soluble form of PEX, PEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PEX, the transmembrane anchor domain has been modified to encode a signal peptidase coding sequence. The soluble PEX therefore comprises the active ectodomain. An inactive mutant of PEX is also an object of this invention. Both soluble and inactive mutant forms of PEX can be used to screen ligands to PEX. These ligands will be used as substrates or inhibitors of PEX. PEX being phosphaturic, an inhibitor thereof will be used to treat phosphaturia and/or hypophosphatemia. On the opposite, a substrate for PEX or PEX itself will be used to treat hyperphosphatemia.
Boileau Guy
Crine Philippe
Goudreau Gage Dubuc
Universite de Montreal
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