Composition of a novel immunogen for protection against...

A - Human Necessities – 61 – K

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A61K 39/108 (2006.01) A61K 39/106 (2006.01)

Patent

CA 1183453

COMPOSITION OF A NOVEL IMMUNOGEN FOR PROTECTION AGAINST DIARRHEAL DISEASE CAUSED BY ENTEROTOXIGENIC Escherlchia coli ABSTRACT OF THE DISCLOSURE There is disclosed a novel immunogen which can be used for immunological protection against acute diar- rheal disease caused by enterotoxigenic strains of Escherichia coli. The novel immunogen is provided by cross-linking the E. coli heat-stable enterotoxin with the E. coli heat-labile enterotoxin (either the complete holotoxin or just the B subunit of this toxin) by a con- jugation process in the presence of a conjugating agent, typically the water soluble carbodiimide, 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide. This results in a unique new molecule in that the toxic properties of each individual toxin are greatly reduced, the heat-labile toxin (or its B subunit) retains its antigenicity, and the heat-stable toxin acquires immunogenicity as a func- tion of the reaction. Immunization with the cross- linked immunogen provides immunological protection in mammals against water secretion induced by strains of E. coli which produce the heat-labile or heat-stable enterotoxins, either singly or together.

405617

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