Composition of antibody capable of specifically binding ccr4

Details Composition of antibody capable of specifically binding ccr4 Composition of antibody capable of specifically binding ccr4

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2542037

A composition of antibody molecules capable of specifically binding human CC chemokine receptor (CCR4), the antibody molecules having in the Fc region thereof a conjugated sugar chain with an N-glycoside linked therewith, wherein the conjugated sugar chain with an N-glycoside linked therewith is a sugar chain having fucose not linked with the N-acetylglucosamine being a reduced terminal of the conjugated sugar chain. There are further provided a transformant capable of producing the antibody composition, a process for producing the antibody composition and a medical drug containing the antibody composition.

La présente invention concerne une composition de molécules anticorps capables de se lier spécifiquement au récepteur de chimiokine CC humain (CCR4), cette molécule anticorps possédant dans la région Fc une chaîne de sucre conjuguée avec un N-glycoside lié à cette chaîne, cette chaîne de sucre conjuguée étant une chaîne de sucre possédant un fucose non liée à la N-acétylglucosamine qui est un terminal réduit de cette chaîne de sucre conjugué. Cette invention concerne aussi un intermédiaire capable de produire cette composition d'anticorps, un processus de production de cette composition d'anticorps et un médicament contenant cette composition d'anticorps.

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