C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) C07H 21/02 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2735167
The present invention provides double-stranded RNA molecules that are asymmetrical in strand length. The RNA molecule of the invention, the asymmetric RNA duplex, has one or two overhangs at the end. In one aspect, these novel RNA duplex molecules serve as effective mimetics of miRNA. In another aspect, they are designed to function as effective inhibitors of miRNA. Accordingly, the RNA molecules of the present invention can be used to modulate miRNA pathway activities, with tremendous implications for research, drug discovery and development, and treatment of human diseases.
La présente invention concerne des molécules d'ARN double brin qui sont symétriques sur la longueur du brin. La molécule d'ARN de l'invention, l'ARN duplex asymétrique, comporte un ou deux débordements à son extrémité. Selon une variante, ces nouvelles molécules duplex d'ARN servent de mimétiques efficaces des micro ARN (miRNA). Selon un autre aspect, elles sont conçues pour fonctionner comme des inhibiteurs efficaces des miRNA. En conséquence, les molécules d'ARN de la présente invention peuvent être utilisées pour moduler les activités de la voie des miRNA, avec de prodigieuses implications dans la recherche, la découverte et le développement de médicaments et le traitement de pathologies humaines.
Li Chiang Jia
Rogoff Harry
Boston Biomedical Inc.
Gowling Lafleur Henderson Llp
LandOfFree
Composition of asymmetric rna duplex as microrna mimetic or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition of asymmetric rna duplex as microrna mimetic or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition of asymmetric rna duplex as microrna mimetic or... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1463930