A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2681790
This invention relates to a composition of labeled and non-labeled monoclonal antibodies directed to a human transmembrane protein for the simultaneous treatment and diagnosis of diseases which are associated with an overexpression of such a protein especially of cancer. The invention further relates to a method of first administering said composition, determine the change of labeled antibody concentration and afterwards administering the non-labeled monoclonal antibodies only such that the minimum required concentration of such non-labeled antibody for a favorable therapeutical effect is achieved and maintained in the treatment, while unfavorable side effects are minimized due to the lower systemic antibody concentration.
L'invention porte sur une composition d'anticorps monoclonaux marqués et non-marqués dirigés vers une protéine de transmembrane humaine pour le traitement et le diagnostic simultanés de maladies associées à une surexpression d'une telle protéine, particulièrement le cancer. L'invention porte en outre sur une méthode consistant: à administrer d'abord les anticorps monoclonaux marqués; à déterminer la modification de la concentration des anticorps marqués; puis à administrer les anticorps monoclonaux non-marqués seulement jusqu'à ce leur concentration ait atteint le niveau minimum requis pour obtenir un effet thérapeutique favorable; puis à poursuivre le traitement, les effets secondaires défavorables étant réduits du fait de la faible concentration des anticorps systémiques.
Lenz Helmut
Scheuer Werner
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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