Composition of matter and method of immunizing against viral...

A - Human Necessities – 61 – K

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167/130, 167/44

A61K 39/12 (2006.01) C07K 17/08 (2006.01) C12Q 1/70 (2006.01) C07K 7/10 (1990.01)

Patent

CA 1293188

ABSTRACT OF THE DISCLOSURE Composition and method for induction of a neutralizing anti- body against the viral causative agents of AIDS and ARC. The composition is a conjugate of a polyamide resin and a synthetic peptide, the amino acid sequence of the synthetic peptide being sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV- III, LAV or ARC to produce an immunogenic response in an experi- mental animal and having a hydrophilic region therein. The com- position is given with or without an adjuvant in an amount effec- tive to induce an immunogenic response, thereby protecting the experimental animal from exposure to the HTLV-III, LAV and/or ARV causative agents of AIDS and/or ARC. 01/MFM2

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