A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/02 (2006.01) A01N 3/00 (2006.01) A61K 47/48 (2006.01) C07K 14/46 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2074162
The present invention relates to aqueous composition of substances, such as organic molecules, which are useful to protect and preserve viable plant or animal cell membrane and tissue exposed to hypothermal and hyperthermal temperatures or non-physiological chemical conditions, and to modify the freezing process of liquids in biological plant or animal cells or tissue. More specifically, the present invention relates to the use of antifreeze polypeptide or antifreeze glycopeptide which is derived, for example, from the fluid or serum of Arctic and Antarctic fish. Preferred antifreeze compounds are related to those polypeptides having multiple alanine-alanine-threonine- or alanine-alanine-alanine-segments.
L'invention concerne des compositions aqueuses de substances telles que des molecules organiques qui sont utiles pour protéger et préserver la membrane et les tissus de cellules végétales ou animales viables exposés à des températures hypothermiques et hyperthermiques ou à des conditions chimiques non physiologiques, et pour modifier le processus de congélation de liquide dans des tissus ou cellules végétales ou animales biologiques. Plus particulièrement, l'invention concerne l'utilisation d'un polypeptide antigel ou d'un glycopeptide antigel qui est dérivé par exemple du fluide ou du serum de poisson de l'Arctique ou de l'Antarctique. Des composés antigels préférés sont apparentés à ces polypeptides ayant des segments multiples d'alanine-alanine-thréonine ou alanine-alanine-alanine.
Devries Arthur L.
Rubinsky Boris
Kirby Eades Gale Baker
The Regents Of The University Of California
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