Composition useful for the prevention of the adverse effect...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/205 (2006.01) A61K 31/365 (2006.01) A61K 31/4439 (2006.01) A61P 19/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2687154

The present invention relates to the use of acetyl L-carnitine, or a pharmaceutically acceptable salt thereof, for the prevention of theadverse effects,such as steoporosis, weight gain and edema, due to the use ofPPAR-gamma agonists selected from the group consisting of spirolaxine or a glitazonederivative selected fromthe group consisting ofroglitazone, pioglitazone androsiglitazone.

La présente invention porte sur l'utilisation de la L-carnitine acétyle, ou d'un sel pharmaceutiquement acceptable de celle-ci, pour la prévention d'effets secondaires, tels que l'ostéoporose, le gain de poids et un AEdème, dus à l'utilisation d'agonistes de PPAR-gamma choisis dans le groupe constitué par la spirolaxine ou un dérivé de glitazone choisi dans le groupe constitué par la roglitazone, la pioglitazone et la rosiglitazone.

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