Compositions

Details Compositions Compositions

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 33/32 (2006.01)

Patent

CA 2197466

There is provided a contrast medium composition comprising a physiologically tolerable manganese compound, an uptake promoter and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3mM or being in a dosage unit form containing at least 300 µmol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, a physiologically tolerable acid containing .alpha.- and/or .beta.-hydroxy or amino groups, or a salt thereof, and/or vitamin D. Such compositions are particularly suitable for imaging of the liver.

On décrit une composition de milieu de contraste qui contient un composé à base de manganèse tolérable du point de vue physiologique, un promoteur d'absorption et un vecteur ou excipient tolérable du point de vue physiologique. Sa concentration en manganèse est d'au moins 0,3 mM mais elle peut aussi se présenter sous une forme galénique contenant au moins 300 µmol de manganèse. Le promoteur d'absorption comprend un composé réducteur, tolérable du point de vue physiologique, qui contient un groupe .alpha.-hydroxy cétone, un acide tolérable du point de vue physiologique et contenant des groupes .alpha. et/ou .beta.-hydroxy ou amino ou un de leurs sels, et/ou de la vitamine D. Ces compositions conviennent particulièrement pour l'imagerie du foie.

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