Compositions affecting hyaluronic acid mediated activity

Details Compositions affecting hyaluronic acid mediated activity Compositions affecting hyaluronic acid mediated activity

C - Chemistry, Metallurgy

08

B

C08B 37/08 (2006.01) A61B 6/00 (2006.01) A61K 9/70 (2006.01) A61K 31/728 (2006.01) A61K 38/10 (2006.01) A61L 15/44 (2006.01) A61L 17/00 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C08L 5/08 (2006.01) G01N 33/53 (2006.01) G01T 1/161 (2006.01)

Patent

CA 2702366

Compositions comprising hyaluronic acid (HA) or agents that interfere with HA binding of HA receptors and methods of using the same are provided. For example, there is provided a composition comprising HA oligomers ranging in size from 10-mer to 80-mer and use of the same for promoting migration, growth or survival of wild-type or transformed/cancerous cells. There is also provided a composition comprising an agent that interferes with binding between an HA oligomer of a size of about 10-mer to about 80-mer and an HA receptor. Such compositions may be useful for therapeutic, diagnostic or imaging applications. Examples of therapeutic use are wound repair or cancer treatment.

L'invention porte sur des compositions comportant de l'acide hyaluronique (HA) ou des agents qui interfèrent avec la liaison à HA de récepteurs de HA, et sur des procédés d'utilisation de ces compositions. L'invention propose, par exemple, une composition comportant des oligomères de HA allant de 10-mère à 80-mère, et sur une utilisation de cette composition pour favoriser la migration, la croissance ou la survie de cellules du type sauvage ou transformées/cancéreuses. L'invention propose également une composition comprenant un agent qui interfère avec la liaison entre un oligomère de HA de taille d'environ 10-mère à environ 80-mère et un récepteur de HA. De telles compositions peuvent être utiles pour des applications thérapeutiques, de diagnostic ou d'imagerie. Des exemples d'utilisation thérapeutique sont la réparation de lésions ou le traitement du cancer.

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