Compositions and delivery methods for the treatment of...

Details Compositions and delivery methods for the treatment of... Compositions and delivery methods for the treatment of...

A - Human Necessities

61

K

A61K 8/97 (2006.01) A61Q 15/00 (2006.01)

Patent

CA 2552442

The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, wherein the compositions include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions of skeletal muscle so as to relax the muscles involved with wrinkling, folding and creasing of skin, e.g., facial movement and expression. The limonoids preferably include the plant alkaloids toosendanin and azadirachtin. The compositions, which also are used to treat hyperhidrosis, are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

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