A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 8/63 (2006.01) A61K 8/04 (2006.01) A61K 8/14 (2006.01) A61K 8/49 (2006.01) A61K 8/97 (2006.01) A61K 31/00 (2006.01) A61K 31/01 (2006.01) A61K 31/045 (2006.01) A61K 31/365 (2006.01) A61K 45/06 (2006.01) A61Q 17/04 (2006.01) A61Q 19/00 (2006.01) A61Q 19/08 (2006.01)
Patent
CA 2470201
The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, wherein the compositions include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions of skeletal muscle so as to relax the muscles involved with wrinkling, folding and creasing of skin, e.g., facial movement and expression. The limonoids preferably include the plant alkaloids toosendanin and azadirachtin. The compositions, which also are used to treat hyperhidrosis, are preferably applied to the skin, or are delivered by directed means to a site in need thereof.
L'invention concerne des compositions et des méthodes pour traiter, prévenir et améliorer l'aspect de la peau, en particulier pour traiter, prévenir, améliorer, réduire et/ou éliminer les ridules et/ou les rides de la peau. Les compositions renferment des constituants limonoïdes qui inhibent la libération d'acétylcholine aux jonctions neuromusculaires de muscle squelettique afin de relâcher les muscles intervenant dans le plissement et le froncement de la peau, p. ex. mouvement et expression faciaux. Les limonoïdes comprennent de préférence la toosendanine et l'azadirachtine, des alcaloïdes d'origine végétale. Ces compositions, qui servent également à traiter l'hyperhidrose, sont de préférence appliquées sur la peau ou sont administrées, par des moyens dirigés, à un site nécessitant un tel traitement.
Duggan Michele C.
Kalafsky Robert E.
Lu Michelle Zheng
Avon Products Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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