A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/42 (2006.01) A61K 9/06 (2006.01) A61K 9/08 (2006.01) A61K 9/70 (2006.01) A61K 31/165 (2006.01) A61K 31/24 (2006.01) A61K 31/245 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/30 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/40 (2006.01)
Patent
CA 2446060
A pharmaceutical composition is provided for topical administration of a local anesthetic agent. The composition comprises (a) a therapeutically effective amount of a local anesthetic agent and (b) a pharmaceutically acceptable, nonliposomal carrier comprised of a monohydric alcohol, a penetration enhancer, and polymer, which may be a hydrophilic polymer, a hydrophobic polymer or a combination thereof. The composition can be in the form of a gel, or it may form a film following application to a patient's body surface and evaporation of the monohydric alcohol. The composition provides rapid onset of local anesthesia as well as penetration of the active agent into the skin. Methods and drug delivery systems for administration of local anesthetic agents are also provided.
L'invention concerne une composition pharmaceutique destinée à l'administration topique d'un anesthésique local. La composition comprend: a) une quantité thérapeutiquement effective d'un anesthésique local; et b) un support non liposomique pharmaceutiquement acceptable comprenant un alcool monohydrique, un activateur de pénétration, et un polymère (qui peut être un polymère hydrophile, un polymère hydrophobe, ou une combinaison des deux polymères). La composition peut se présenter sous la forme d'un gel, ou d'un film après application à la surface du corps d'un patient et évaporation de l'alcool monohydrique. La composition assure un début rapide de l'anesthésique local ainsi que la pénétration du principe actif dans la peau. L'invention concerne en outre des méthodes et des systèmes d'administration d'anesthésiques locaux.
Birudaraj Raj
Cleary Colin J.
Cleary Gary W.
Mudumba Sri
Parandoosh Shoreh
Battison Williams Dupuis
Corium International
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