Compositions and diagnostic methods using monoclonal...

Details Compositions and diagnostic methods using monoclonal... Compositions and diagnostic methods using monoclonal...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C07K 14/705 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2165461

Monoclonal antibody (DSM ACC1213) which binds only to forms of CD44 containing the amino acid sequence encoded by exon v6, but not to the 90 kilodalton standard lymphocyte form of CD44 and the use of such antibodies for detecting the presence of CD44v6 in tissues or cells, for determining if epithelial tissue from an animal or human has undergone malignant transformation, for determining the metastatic potential of malignant cells and for detecting inflammatory diseases in patients.

L'invention concerne un anticorps monoclonal (DSM ACC 1213) qui ne fixe que les formes du CD44 contenant la séquence d'acides aminés codée par l'exon v6 et non sa forme courante de lymphocyte de 90 kilodaltons. Elle concerne également l'utilisation de ce type d'anticorps pour détecter la présence de CD44v6 dans des tissus ou des cellules, déterminer si un tissu épithélial provenant d'un animal ou d'un humain a subi une transformation maligne, établir le potentiel métastatique de cellules malignes et détecter des maladies inflammatoires.

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