A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/185 (2006.01) A61K 31/20 (2006.01) A61P 3/10 (2006.01) C07C 229/08 (2006.01) C07C 229/28 (2006.01)
Patent
CA 2543181
A complex comprised of gabapentin or pregabalin and a transport moiety, such as an alkyl sulfate, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of the drug through a period of ten to twenty-four hours, thus enabling a once-daily dosage form for gabapentin or pregabalin.
L'invention concerne un complexe comprenant de la gabapentine ou de la prégabaline et une fraction de transport, telle qu'un sulfate d'alkyle. Le complexe présente une absorption améliorée dans le tractus gastro-intestinal, en particulier dans le tractus gastro-intestinal inférieur. Le complexe, les compositions et les formes posologiques préparées au moyen du complexe, permettent une absorption du médicament par le corps, sur une période comprise entre dix et vingt-quatre heures, ceci permettant l'obtention d'une forme posologique journalière de gabapentine ou de prégabaline.
Guittard George V.
Wong Patrick S. L.
Yan Dong
Alza Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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