Compositions and dosage forms for enhanced absorption of...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/155 (2006.01) A61K 31/20 (2006.01) A61P 3/10 (2006.01) C07C 279/00 (2006.01)

Patent

CA 2543177

A complex comprised of metformin and a transport moiety, such as a fatty acid, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of the drug through a period of ten to twenty-four hours, thus enabling a once-daily dosage form for metformin.

L'invention concerne un complexe comprenant de la metformine et une fraction de transport, telle qu'un acide gras. Le complexe présente une absorption améliorée dans le tractus gastro-intestinal, en particulier dans le tractus gastro-intestinal inférieur. Le complexe, les compositions et les formes posologiques préparées au moyen du complexe, permettent une absorption du médicament par le corps, sur une période comprise entre dix et vingt-quatre heures, ceci permettant l'obtention d'une forme posologique journalière de metformine.

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