A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4738 (2006.01) A61K 9/14 (2006.01) C07D 491/147 (2006.01) C07D 491/22 (2006.01)
Patent
CA 2476630
Polymorphic forms of 9-nitrocamptothecin (9NC) are provided. Distinct crystal forms of 9NC are obtained from crystallization in different solvent systems and under various conditions, and are further charactherized using various analytical methods. For example, a particular crystal form of 9NC is provided which is charactherizable as having, by differential scanning calorimetry, an endotherm at between 175.5 and 177.2C, an exotherm at between 181.7 and 183.7C, and an IR spectrum with no absorption centered between 3625cm-1 and 3675cm-1.
L'invention concerne des formes polymorphes de 9-nitrocamptothécine (9NC) . Différentes formes crystallines de 9NC peuvent être obtenues à partir de la cristallisation dans différents systèmes de solvants et dans diverses conditions, et sont également caractérisées à l'aide de divers procédés analytiques. Par exemple, une forme crystalline particulière de 9NC est prévue qui se caractérise, par une calorimétrie de balayage différentiel, en ce qu'elle possède un endotherme compris entre 175n5 et 177,5·C, un exotherme compris entre 181,7 et 183,7·C et un spectre IR sans absorption centré entre 3625 cm?-1¿ et 3675 cm?-1¿.
Gore Ashok Y.
Redkar Sanjeev
Borden Ladner Gervais Llp
Supergen Inc.
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