Compositions and kits comprising alpha-adrenergic receptor...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/505 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) A61K 38/06 (2006.01) A61K 47/48 (2006.01) C07C 381/00 (2006.01) C07D 211/62 (2006.01) C07D 233/24 (2006.01) C07D 239/95 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01) C07D 459/00 (2006.01) C07K 5/037 (2006.01)

Patent

CA 2244879

Disclosed are nitrosated and nitrosylated .alpha.-adrenergic receptor antagonists, compositions of an .alpha.-adrenergic receptor antagonist (.alpha.-antagonist), which can optionally be substituted with at least one NO or NO2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO-), or as the neutral species, nitric oxide (NO.); and uses for each of them in treating human impotence or erectile dysfunction.

L'invention se rapporte à des antagonistes nitrosés ou nitrosylés du récepteur .alpha.-adrénergique, à des compositions d'un antagoniste du récepteur .alpha.-adrénergique (.alpha.-antagoniste), qui peuvent être éventuellement substitués par au moins une fraction NO ou NO¿2?, et à un composant qui donne, transfère ou libère l'acide nitrique sous forme d'une espèce chimique chargée, à savoir, nitrosonium (NO?+¿) ou nitroxyle (NO?-¿), ou sous forme de l'espèce neutre, l'oxyde nitrique (NO.). L'invention se rapporte également à chacune des utilisations de ces antagonistes dans le traitement de l'impuissance masculine ou dysérection.

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