Compositions and method for the treatment or prophylaxis of...

Details Compositions and method for the treatment or prophylaxis of... Compositions and method for the treatment or prophylaxis of...

A - Human Necessities

61

K

167/139, 167/103

A61K 39/40 (2006.01) A61K 38/48 (2006.01)

Patent

CA 1339990

Pharmaceutical compositions useful for the treatment or prophylaxis of Gram-negative bacteremia or septic shock contain a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The compositions may further contain one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins. A method for the treatment or prophylaxis of Gram-negative bacteremia or septic shock comprises administering, either together or separately, a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The method may optionally include administering one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.

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