Compositions and method for transmucosal drug delivery and...

Details Compositions and method for transmucosal drug delivery and... Compositions and method for transmucosal drug delivery and...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 9/00 (2006.01) A61K 9/02 (2006.01) A61K 9/48 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/277 (2006.01) A61K 31/337 (2006.01) A61K 31/405 (2006.01) A61K 31/407 (2006.01) A61K 31/5415 (2006.01) A61K 31/616 (2006.01) A61K 31/663 (2006.01) A61K 38/11 (2006.01) A61K 38/20 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01)

Patent

CA 2486909

Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a no-ionizable glycol derivative. For transmucosal delivery, the compositions essentially consist of a non-ionizable glycol derivative in a combination with a pharmaceutically active agent. For transmucosal delivery, the non-ionizable glycol derivative may be further combined with a mucoadhesive agent and/or a penetration enhancer and/or lipophilic or hydrophilic carrier for adhesion to and transport through a mucosa. The compositions are particularly suitable for administration of drugs through a nasal, buccal and vaginal mucosa or for long- term preservation of cell or embryos.

L'invention concerne des compositions et des méthodes d'administration transmuqueuse de médicaments par voie vaginale, orale ou nasale et de cryoprotection de cellules et d'embryons. Pour la cryoprotection, la composition est principalement composée d'un dérivé de glycol non ionisable. Pour l'administration transmuqueuse, les compositions sont principalement composées d'un dérivé de glycol non ionisable combiné à un pharmaceutiquement actif et le dérivé de glycol non ionisable peut également être combiné avec un agent mucoadhésif et/ou un activateur de pénétration et/ou un tensioactif lipophile ou hydrophile afin de coller à une muqueuse et d'être transporté par une muqueuse. Les compositions selon l'invention conviennent particulièrement pour une administration de médicaments par une muqueuse nasale, orale ou vaginale ou pour une conservation à long terme de cellules ou d'embryons.

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