C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/140
C12N 5/12 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 1341374
Cell surface gangliosides are presumed to play a role in cell growth and differentiation. Using monoclonal antibodies directed against G D3, a disialoganglioside expressed predominantly by cells of neuroectodermal origin, we have found that G D3 is expressed by a subpopulation of cells of the immune system including: a) fetal thymocytes in subcortical regions and near vessels, 2) lymph node lymphocytes in interfollicular areas and near vessels, and 3) a small subset of T cells in the peripheral blood. Mouse monoclonal antibodies (two IgGs, one IgM and F(ab')2 fragments) reacting with G D3 were found to stimulate proliferation of T cells derived from peripheral blood. Proliferation induced by binding to G D3 could be augmented by exogenous IL-2, PMA, PHA or Protein A.
551669
Chapman Paul
Houghton Alan N.
Miller Glenn
Old Lloyd J.
Welte Karl
Gowling Lafleur Henderson Llp
Sloan-Kettering Institute For Cancer Research
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