Compositions and methods comprising binding proteins for...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/42 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2696210

Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-a and was developed to treat TNF-a mediated inflammatory diseases. In one aspect of the instant invention, the binding proteins are antibodies directed toward adalimumab. These antibodies, including binding fragments thereof, can be used in a clinical setting as well as for research and development. For example, these anti-adalimumab antibodies can be employed to neutralize adalimumab.

L'invention porte sur des compositions et des procédés comprenant des protéines qui se lient spécifiquement à adalimumab. Adalimumab est un anticorps monoclonal spécifique de la cytokine du TNF-a et a été développé pour traiter des maladies inflammatoires induites par TNF-a. Selon un aspect de la présente invention, les protéines de liaison sont des anticorps dirigés contre adalimumab. Ces anticorps, comprenant des fragments de liaison de ceux-ci, peuvent être utilisés dans un milieu clinique, ainsi que dans la recherche et le développement. Par exemple, ces anticorps anti-adalimumab peuvent être employés pour neutraliser adalimumab.

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