Compositions and methods employing nmda antagonists for...

Details Compositions and methods employing nmda antagonists for... Compositions and methods employing nmda antagonists for...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/08 (2006.01) A61K 31/675 (2006.01) A61P 23/00 (2006.01)

Patent

CA 2697739

Provided herein are compositions, combinations, and methods comprising NMDA antagonists including, but not limited to, NMDA glutamate receptor antagonists such as [2-(8,9-dioxo-2,6- diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof, which are effective in reducing the amount of anesthetic required to maintain anesthesia (i.e. to achieve an anesthetic-sparing effect).

L'invention propose des compositions, des combinaisons et des procédés comportant des antagonistes de NMDA comprenant, mais sans s'y limiter, des antagonistes des récepteurs du glutamate NMDA tels que l'acide [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonique et des dérivés de celui-ci, qui sont efficaces dans la réduction de la quantité d'anesthésique nécessaire pour maintenir l'anesthésie (à savoir, pour obtenir un effet d'épargne de l'anesthésique).

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