Compositions and methods for altering gene expression

Details Compositions and methods for altering gene expression Compositions and methods for altering gene expression

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01K 67/027 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2385162

Disclosed are novel compositions and methods useful for modulating expression of a target gene in a cell by insertion of exogenous DNA sequence into the target gene. The compositions and methods of the invention are useful for generation of knockout animals including mammals.

L'invention concerne de nouvelles compositions et méthodes pouvant moduler l'expression d'un gène cible dans une cellule, par insertion d'une séquence d'ADN exogène dans le gène cible. Les compositions et méthodes de l'invention sont utiles pour la production d'animaux à gène inactivé, notamment de mammifères.

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