Compositions and methods for altering the biodistribution of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 9/66 (2006.01) A61K 31/70 (2006.01) A61K 41/00 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2258882

The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.

L'invention porte sur une nouvelle composition pharmaceutique améliorée et sur une méthode d'administration d'agents thérapeutiques pouvant s'utiliser avec divers agents thérapeutiques et permettre d'administrer une substance thérapeutique ou diagnostique en des sites spécifique. On peut donc utiliser des doses plus faibles ou obtenir une efficacité plus grande avec des médicaments atteignant traditionnellement les sites cibles ou obtenir de meilleurs résultats avec des agents tels que les oligonucléotides et les polynucléotides handicapés par des problèmes de biodistribution.

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