Compositions and methods for ameliorating cachexia

Details Compositions and methods for ameliorating cachexia Compositions and methods for ameliorating cachexia

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/13 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2646131

The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial ingredients that are serviceable as therapies for improving states and disease symptoms such as involving inflammation, excessive sympathoneural drive, cachexia, anorexia, and anorexia-cachexia, as well as stress or anxiety related thereto, and methods of making and using them. The invention provides compositions and therapies comprising use of a beta adrenergic antagonist (also called "beta blockers", e.g., propranolol) in combination with an anti- inflammatory agent, e.g., a nonsteroidal anti-inflammatory drug (NSAID), an angiotensin-converting enzyme (ACE) inhibitor, an angiotensin receptor blocker (ARB), an anabolic steroid, a natural oil or fatty acid or any combination thereof.

L'invention porte sur des préparations, des formulations, des trousses et autres produits manufacturés (p.ex., des emballages-coques) comprenant des combinaisons d'ingrédients bénéfiques pouvant être utilisés comme thérapies pour améliorer les états et les symptômes pathologiques tels que l'inflammation, une stimulation sympathoneurale excessive, la cachexie, l'anorexie, et l'anorexie-cachexie, ainsi que le stress et l'anxiété qui leurs sont associés, et sur des procédés de fabrication et d'utilisation de ces derniers. L'invention concerne des compositions et des thérapies qui font appel à un antagoniste bêta-adrénergique (appelé également "bêta-bloquant", tel que le propranolol) combiné à un agent anti-inflammatoire, p.ex. un médicament anti-inflammatoire non stéroïdien (AINS), un inhibiteur de l'enzyme de conversion de l'angiotensine (ECA), un agent bloquant le récepteur de l'angiotensine (BRA), un anabolisant stéroïdien, une huile naturelle ou un acide gras ou une quelconque combinaison de ces derniers.

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