A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/381 (2006.01) A61K 31/711 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2702494
The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post- operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C3 (tris malonic acid C60) or malonic acid derivatives.
L'invention a pour objets des compositions et des procédés permettant d'améliorer, de traiter, d'inverser ou de prévenir une pathologie ou une inflammation du système nerveux central (SNC) ou du cerveau, provoquée ou initiée par le NFkB, l'IL-6, l'IL-6-R, l'oxydase NADPH (Nox) et/ou la production de superoxyde et/ou de peroxyde d'hydrogène par une oxydase NADPH, et permettant notamment d'améliorer, de traiter, d'inverser ou de prévenir la schizophrénie, la psychose, le délire, par exemple le délire post-opératoire, la psychose médicamenteuse, les caractéristiques psychotiques associées au syndrome de fragilité, le vieillissement, la dépression, la démence, la névrose post-traumatique de guerre, le trouble de stress post-traumatique (PTSD) ou le syndrome de stress post-traumatique (SSPT), la sclérose latérale amyotrophique (SLA ou maladie de Lou Gehrig) et/ou la sclérose en plaques (SEP). L'invention a également pour objet des procédés de purification d'un fullerène C60 et de dérivés C3 (tris (acide malonique) C60) ou de dérivés d'acide malonique.
Ali Sameh S.
Behrens Marie Margarita
Dugan Laura L.
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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