A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/713 (2006.01) A61K 31/135 (2006.01) A61K 31/695 (2006.01) A61P 3/06 (2006.01) A61P 31/12 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2654183
The invention provides compositions and methods for treating hyperlipidemia by administering a Microsomal Triglyceride Transfer Protein (MTP) inhibitor in combination with a Liver Fatty Acid-Binding Protein (L-FABP) inhibitor, methods of preventing the development of hepatic steatosis, methods of identifying an agent useful for treating hyperlipidemia, and methods of screening for inhibitors of MTP and L-FABP activity. Also provided are pharmaceutical compositions comprising a MTP inhibitor and a L-FABP inhibitor.
L'invention propose des compositions et des procédés pour traiter l'hyperlipidémie par administration d'un inhibiteur de la Protéine Microsomale de Transfert des Triglycérides (MTP) en combinaison avec un inhibiteur de la Protéine de Liaison aux Acides Gras du Foie (L-FABP), des procédés pour empêcher le développement de la stéatose hépatique, des procédés pour identifier un agent utile pour traiter l'hyperlipidémie et des procédés pour cribler les inhibiteurs de l'activité de MTP et de L-FABP. Sont également proposées des compositions pharmaceutiques comportant un inhibiteur de MTP et un inhibiteur de L-FABP.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
San Diego State University Research Foundation
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