C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) C12N 1/20 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2620934
The present invention relates to compositions and methods for analyzing and modulating (e.g., enhancing or inhibiting) protein-protein interactions. In particular, compositions and methods of the present invention find use in identifying, reconstituting and characterizing protein-protein interactions, identifying binding subunits, and drug screening. The methods and compositions of the invention may also be used to identify agents that may agonize or antagonize a protein-protein interaction (e.g., using test compounds).
Cette invention concerne des compositions et des méthodes permettant d'analyser et de moduler (par exemple de renforcer ou d'inhiber) des interactions protéine-protéine. En particulier, les compositions et méthodes de cette invention sont utilisées pour identifier, reconstituer et caractériser des interactions protéine-protéine, pour identifier des sous-unités de liaison ainsi que pour effectuer le criblage de médicaments. Les méthodes et compositions de cette invention peuvent également être utilisées pour identifier des agents pouvant avoir un effet agoniste ou antagoniste sur une interaction protéine-protéine (par exemple à l'aide de composants tests).
Delisa Matthew
Georgiou George
Waraho Dujduan
Cornell Research Foundation Inc.
Research Development Foundation
Smart & Biggar
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